abstract：:A positive effect of all-trans retinoic acid (ATRA) on white adipose tissue (WAT) oxidative and thermogenic capacity has been described and linked to an in vivo fat-lowering effect of ATRA in mice. However, little is known about the effects of ATRA on mitochondria in white fat. Our objective has been to characterize t...

journal_title：Journal of lipid research

authors： Tourniaire F,Musinovic H,Gouranton E,Astier J,Marcotorchino J,Arreguin A,Bernot D,Palou A,Bonet ML,Ribot J,Landrier JF

更新日期：2015-06-01 00:00:00

abstract：:Lipoprotein (a) [Lp(a)] is a highly atherogenic lipid particle. Although earlier reports suggested that Lp(a) levels are mostly determined by genetic factors, several recent studies have revealed that Lp(a) induction is also caused by chronic inflammation. Therefore, we aimed to examine whether cytokine blockade by mo...

journal_title：Journal of lipid research

authors： Müller N,Schulte DM,Türk K,Freitag-Wolf S,Hampe J,Zeuner R,Schröder JO,Gouni-Berthold I,Berthold HK,Krone W,Rose-John S,Schreiber S,Laudes M

更新日期：2015-05-01 00:00:00

abstract：:ABCA1 plays a key role in the initial lipidation of apoA-I, which generates circulating HDL cholesterol. Whereas it is known that the transcriptional upregulation of ABCA1 promotes HDL formation and reverse cholesterol transport (RCT), it is not known how the inhibition of ABCA1 protein degradation impacts HDL functio...

journal_title：Journal of lipid research

authors： Huang L,Fan B,Ma A,Shaul PW,Zhu H

更新日期：2015-05-01 00:00:00

abstract：:The endocannabinoid 2-arachidonoylglycerol (2-AG) is predominantly biosynthesized by sn-1-diacylglycerol lipase α (DAGL-α) in the CNS. Selective inhibitors of DAGL-α will provide valuable insights in the role of 2-AG in endocannabinoid signaling processes and are potential therapeutics for the treatment of obesity and...

journal_title：Journal of lipid research

authors： van der Wel T,Janssen FJ,Baggelaar MP,Deng H,den Dulk H,Overkleeft HS,van der Stelt M

更新日期：2015-04-01 00:00:00

abstract：:The spectrum of nonalcoholic fatty liver disease (NAFLD) includes steatosis, nonalcoholic steatohepatitis (NASH), and cirrhosis. Recognition and timely diagnosis of these different stages, particularly NASH, is important for both potential reversibility and limitation of complications. Liver biopsy remains the clinica...

journal_title：Journal of lipid research

authors： Gorden DL,Myers DS,Ivanova PT,Fahy E,Maurya MR,Gupta S,Min J,Spann NJ,McDonald JG,Kelly SL,Duan J,Sullards MC,Leiker TJ,Barkley RM,Quehenberger O,Armando AM,Milne SB,Mathews TP,Armstrong MD,Li C,Melvin WV,Clemen

更新日期：2015-03-01 00:00:00

abstract：:ABCB4, which is specifically expressed on the canalicular membrane of hepatocytes, exports phosphatidylcholine (PC) into bile. Because SM depletion increases cellular PC content and stimulates PC and cholesterol efflux by ABCA1, a key transporter involved in generation of HDL, we predicted that SM depletion also stimu...

journal_title：Journal of lipid research

authors： Zhao Y,Ishigami M,Nagao K,Hanada K,Kono N,Arai H,Matsuo M,Kioka N,Ueda K

更新日期：2015-03-01 00:00:00

abstract：:apoM is a member of the lipocalin superfamily and circulates in plasma attached to HDL particles. apoM plays a role in cholesterol metabolism and has recently been identified as transporter for the signaling lipid, sphingosine-1-phosphate (S1P), in plasma. S1P is implicated in several inflammatory diseases such as mul...

journal_title：Journal of lipid research

authors： Bosteen MH,Dahlbäck B,Nielsen LB,Christoffersen C

更新日期：2015-03-01 00:00:00

abstract：:Autophagy is a catabolic process involved in maintaining energy and organelle homeostasis. The relationship between obesity and the regulation of autophagy is cell type specific. Despite adverse consequences of obesity on cardiac structure and function, the contribution of altered cardiac autophagy in response to fatt...

journal_title：Journal of lipid research

authors： Jaishy B,Zhang Q,Chung HS,Riehle C,Soto J,Jenkins S,Abel P,Cowart LA,Van Eyk JE,Abel ED

更新日期：2015-03-01 00:00:00

abstract：:Nucleoredoxin (NRX) is a member of the thioredoxin family of proteins that controls redox homeostasis in cell. Redox homeostasis is a well-known regulator of cell differentiation into various tissue types. We found that NRX expression levels were higher in white adipose tissue of obese ob/ob mice and increased in the ...

journal_title：Journal of lipid research

authors： Bahn YJ,Lee KP,Lee SM,Choi JY,Seo YS,Kwon KS

更新日期：2015-02-01 00:00:00

abstract：:Retinoic acid (RA), the active metabolite of vitamin A, is required for spermatogenesis and many other biological processes. RA formation requires irreversible oxidation of retinal to RA by aldehyde dehydrogenase enzymes of the 1A family (ALDH1A). While ALDH1A1, ALDH1A2, and ALDH1A3 all form RA, the expression pattern...

journal_title：Journal of lipid research

authors： Arnold SL,Kent T,Hogarth CA,Schlatt S,Prasad B,Haenisch M,Walsh T,Muller CH,Griswold MD,Amory JK,Isoherranen N

更新日期：2015-02-01 00:00:00

abstract：:apoE is a multi-functional protein expressed in several cell types and in several organs. It is highly expressed in adipose tissue, where it is important for modulating adipocyte lipid flux and gene expression in isolated adipocytes. In order to investigate a potential systemic role for apoE that is produced in adipos...

journal_title：Journal of lipid research

authors： Huang ZH,Reardon CA,Getz GS,Maeda N,Mazzone T

更新日期：2015-02-01 00:00:00

abstract：:Effects of serum cholesterol on cholesterol content in the retina are currently unknown. It is also unclear how cholesterol levels are controlled in the retina. High-cholesterol diet and oral administrations of simvastatin were used to modulate serum cholesterol in mice. These treatments only modestly affected cholest...

journal_title：Journal of lipid research

authors： Zheng W,Mast N,Saadane A,Pikuleva IA

更新日期：2015-01-01 00:00:00

abstract：:Elongation of very long chain fatty acid-like family member 6 (ELOVL6) is a fatty acyl elongase that performs the initial and rate-limiting condensing reaction required for microsomal elongation of long-chain fatty acids. Our previous in vitro studies suggested that ELOVL6 elongated long-chain saturated fatty acids an...

journal_title：Journal of lipid research

authors： Moon YA,Ochoa CR,Mitsche MA,Hammer RE,Horton JD

更新日期：2014-12-01 00:00:00

abstract：:Acyl-CoA thioesterase (Acot)2 localizes to the mitochondrial matrix and hydrolyses long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxi-dative tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role is unknown. Using a model of adenoviral Acot2 overexpr...

journal_title：Journal of lipid research

authors： Moffat C,Bhatia L,Nguyen T,Lynch P,Wang M,Wang D,Ilkayeva OR,Han X,Hirschey MD,Claypool SM,Seifert EL

更新日期：2014-12-01 00:00:00

abstract：:Phospholipids serve as central structural components in cellular membranes and as potent mediators in numerous signaling pathways. There are six main classes of naturally occurring phospholipids distinguished by their distinct polar head groups that contain many unique molecular species with distinct fatty acid compos...

journal_title：Journal of lipid research

authors： Baker PR,Armando AM,Campbell JL,Quehenberger O,Dennis EA

更新日期：2014-11-01 00:00:00

abstract：:Transcripts encoding a novel member of the lipoprotein receptor superfamily, termed LDL receptor-related protein (Lrp)13, were sequenced from striped bass (Morone saxatilis) and white perch (Morone americana) ovaries. Receptor proteins were purified from perch ovary membranes by protein-affinity chromatography employi...

journal_title：Journal of lipid research

authors： Reading BJ,Hiramatsu N,Schilling J,Molloy KT,Glassbrook N,Mizuta H,Luo W,Baltzegar DA,Williams VN,Todo T,Hara A,Sullivan CV

更新日期：2014-11-01 00:00:00

abstract：:The melanocortin system is an important regulator of energy balance, and melanocortin 4 receptor (MC4R) deficiency is the most common monogenic cause of obesity. We investigated whether the relationship between melanocortin system activity and energy expenditure (EE) is mediated by brown adipose tissue (BAT) activity....

journal_title：Journal of lipid research

authors： Kooijman S,Boon MR,Parlevliet ET,Geerling JJ,van de Pol V,Romijn JA,Havekes LM,Meurs I,Rensen PC

更新日期：2014-10-01 00:00:00

abstract：:Over the past several years, considerable progress has been made in the development of gene therapy as a therapeutic strategy for a variety of inherited metabolic diseases, including neuropathic lysosomal storage disorders (LSDs). The premise of gene therapy for this group of diseases is borne of findings that genetic...

journal_title：Journal of lipid research

authors： Cheng SH

更新日期：2014-09-01 00:00:00

abstract：:Ketone bodies (KBs), acetoacetate and β-hydroxybutyrate (βHB), were considered harmful metabolic by-products when discovered in the mid-19th century in the urine of patients with diabetic ketoacidosis. It took physicians many years to realize that KBs are normal metabolites synthesized by the liver and exported into t...

journal_title：Journal of lipid research

authors： Hashim SA,VanItallie TB

更新日期：2014-09-01 00:00:00

abstract：:Sphingosine-1-phosphate (S1P) is a bioactive lipid mediator that promotes cell survival, proliferation, migration, angiogenesis, lymphangiogenesis, and immune response; all are critical processes of cancer progression. Although some important roles of intracellular S1P have recently been uncovered, the majority of its...

journal_title：Journal of lipid research

authors： Takabe K,Spiegel S

更新日期：2014-09-01 00:00:00

abstract：:EPA and DHA are not biologically equivalent; however, their individual activity on B cells is unknown. We previously reported fish oil enhanced murine B-cell activity in obesity. To distinguish between the effects of EPA and DHA, we studied the ethyl esters of EPA and DHA on murine B-cell function as a function of tim...

journal_title：Journal of lipid research

authors： Teague H,Harris M,Fenton J,Lallemand P,Shewchuk BM,Shaikh SR

更新日期：2014-07-01 00:00:00

abstract：:Cystic fibrosis (CF) patients and model systems exhibit consistent abnormalities in PUFA metabolism, including increased metabolism of linoleate to arachidonate. Recent studies have connected these abnormalities to increased expression and activity of the Δ6- and Δ5-desaturase enzymes. However, the mechanism connectin...

journal_title：Journal of lipid research

authors： Umunakwe OC,Seegmiller AC

更新日期：2014-07-01 00:00:00

abstract：:The K146N/R147W substitutions in apoE3 were described in patients with a dominant form of type III hyperlipoproteinemia. The effects of these mutations on the in vivo functions of apoE were studied by adenovirus-mediated gene transfer in different mouse models. Expression of the apoE3[K146N/R147W] mutant in apoE-defic...

journal_title：Journal of lipid research

authors： Fotakis P,Vezeridis A,Dafnis I,Chroni A,Kardassis D,Zannis VI

更新日期：2014-07-01 00:00:00

abstract：:Cell death-inducing DFF45-like effector b (Cideb), an endoplasmic reticulum (ER)- and lipid droplet (LD)-associated protein, has been shown to play a critical role in maintaining hepatic lipid homeostasis by promoting the lipidation and maturation of VLDL particles. Here, we observed that Cideb is expressed in the jej...

journal_title：Journal of lipid research

authors： Zhang LJ,Wang C,Yuan Y,Wang H,Wu J,Liu F,Li L,Gao X,Zhao YL,Hu PZ,Li P,Ye J

更新日期：2014-07-01 00:00:00

abstract：:Cyanidin-3-O-β-glucoside (C3G) (CAS number 7084-24-4), a typical anthocyanin pigment that exists in the human diet, has been reported to have anti-inflammatory properties. However, the effect of C3G on lipopolysaccharide (LPS)-induced mastitis and the molecular mechanisms have not been investigated. In this study, we ...

journal_title：Journal of lipid research

authors： Fu Y,Wei Z,Zhou E,Zhang N,Yang Z

更新日期：2014-06-01 00:00:00

abstract：:In an effort to explore the feasibility of converting a lipase into an esterase by modifying the lid region, we designed and characterized two novel Rhizopus chinensis lipase variants by lid swapping. The substrate specificity of an R. chinensis lipase was successfully modified toward water-soluble substrates, that is...

journal_title：Journal of lipid research

authors： Yu XW,Zhu SS,Xiao R,Xu Y

更新日期：2014-06-01 00:00:00

abstract：:Cellular membranes are composed of numerous kinds of glycerophospholipids with different combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 positions, respectively. The glycerophospholipid compositions of different cell types, organelles, and inner/outer plasma membrane leaflets ar...

journal_title：Journal of lipid research

authors： Hishikawa D,Hashidate T,Shimizu T,Shindou H

更新日期：2014-05-01 00:00:00

abstract：:PPARs regulate the expression of genes for energy metabolism in a ligand-dependent manner. PPARs can influence fatty acid oxidation, the level of circulating triglycerides, glucose uptake and insulin sensitivity. Here, we demonstrate that 5-hydroxyeicosapentaenoic acid (HEPE), 8-HEPE, 9-HEPE, 12-HEPE and 18-HEPE (hydr...

journal_title：Journal of lipid research

authors： Yamada H,Oshiro E,Kikuchi S,Hakozaki M,Takahashi H,Kimura K

更新日期：2014-05-01 00:00:00

abstract：:Oxidative stress, hepatic steatosis, and mitochondrial dysfunction are key pathophysiological features of nonalcoholic fatty liver disease. A conjugated linoleic acid (CLA) mixture of cis9,trans11 (9,11-CLA) and trans10,cis12 (10,12-CLA) isomers enhanced the antioxidant/detoxifying mechanism via the activation of nucl...

journal_title：Journal of lipid research

authors： Mollica MP,Trinchese G,Cavaliere G,De Filippo C,Cocca E,Gaita M,Della-Gatta A,Marano A,Mazzarella G,Bergamo P

更新日期：2014-05-01 00:00:00

abstract：:The effect of electron transport chain redox status on activity of the mitochondrial Ca(2+)-independent phospholipase A2 (iPLA2) has been examined. When oxidizing NAD-linked substrates, the enzyme is not active unless deenergization occurs. Uncoupler, rotenone, antimycin A, and cyanide are equally effective at upregul...

journal_title：Journal of lipid research

authors： Rauckhorst AJ,Broekemeier KM,Pfeiffer DR

更新日期：2014-05-01 00:00:00

abstract：:Adipocyte differentiation and function have become areas of intense focus in the field of energy metabolism; however, understanding the role of specific genes in the establishment and maintenance of fat cell function can be challenging and complex. In this review, we offer practical guidelines for the study of adipocy...

journal_title：Journal of lipid research

authors： Wang QA,Scherer PE,Gupta RK

更新日期：2014-04-01 00:00:00

abstract：:Gangliosides and sulfatides (STs) are acidic glycosphingolipids (GSLs) that have one or more sialic acids or sulfate substituents, in addition to neutral sugars, attached to the C-1 hydroxyl group of the ceramide long chain base. TLC is a widely employed and convenient technique for separation and characterization of ...

journal_title：Journal of lipid research

authors： Park H,Zhou Y,Costello CE

更新日期：2014-04-01 00:00:00

abstract：:Lysophospholipid acyltransferases (LPATs) incorporate fatty acyl chains into phospholipids via a CoA-dependent mechanism and are important in remodeling phospholipids to generate the molecular species of phospholipids found in cells. These enzymes use one lysophospholipid and one acyl-CoA ester as substrates. Traditio...

journal_title：Journal of lipid research

authors： Martin SA,Gijón MA,Voelker DR,Murphy RC

更新日期：2014-04-01 00:00:00

abstract：:Autosomal dominant Stargardt-like macular dystrophy (STGD3) in humans results from mutations in elongation of very long chain FAs-like 4 (ELOVL4), which leads to vision loss in young adults. ELOVL4 is an integral endoplasmic reticulum (ER) protein that mediates the elongation of very long chain (VLC) FAs. Mutations in...

journal_title：Journal of lipid research

authors： Logan S,Agbaga MP,Chan MD,Brush RS,Anderson RE

更新日期：2014-04-01 00:00:00

abstract：:ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12(-/-) skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accumulation of GlcCer, de novo sphingolipid synthesis was assayed using [(...

journal_title：Journal of lipid research

authors： Haller JF,Cavallaro P,Hernandez NJ,Dolat L,Soscia SJ,Welti R,Grabowski GA,Fitzgerald ML,Freeman MW

更新日期：2014-03-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder caused by impaired degradation of very long-chain fatty acids (VLCFAs) due to mutations in the ABCD1 gene responsible for VLCFA transport into peroxisomes. Lorenzo's oil, a 4:1 mixture of glyceryl trioleate and glyceryl trierucate, has been used to reduce...

journal_title：Journal of lipid research

authors： Sassa T,Wakashima T,Ohno Y,Kihara A

更新日期：2014-03-01 00:00:00

abstract：:Adipose tissue contains one of the largest reservoirs of cholesterol in the body. Adipocyte dysfunction in obesity is associated with intracellular cholesterol accumulation, and alterations in cholesterol homeostasis have been shown to alter glucose metabolism in cultured adipocytes. ABCA1 plays a major role in choles...

journal_title：Journal of lipid research

authors： de Haan W,Bhattacharjee A,Ruddle P,Kang MH,Hayden MR

更新日期：2014-03-01 00:00:00

abstract：:The tear film covers the anterior eye and the precise balance of its various constituting components is critical for maintaining ocular health. The composition of the tear film amphiphilic lipid sublayer, in particular, has largely remained a matter of contention due to the limiting concentrations of these lipid amphi...

journal_title：Journal of lipid research

authors： Lam SM,Tong L,Duan X,Petznick A,Wenk MR,Shui G

更新日期：2014-02-01 00:00:00

abstract：:Accumulation of foam cells in the neointima represents a key event in atherosclerosis. We previously demonstrated that Tanshinone IIA (Tan), a lipophilic bioactive compound extracted from Salvia miltiorrhiza Bunge, inhibits experimental atherogenesis, yet the detailed mechanisms are not fully understood. In this study...

journal_title：Journal of lipid research

authors： Liu Z,Wang J,Huang E,Gao S,Li H,Lu J,Tian K,Little PJ,Shen X,Xu S,Liu P

更新日期：2014-02-01 00:00:00

abstract：:There is a continuous flux of the oxysterol 27-hydroxycholesterol (27-OHC) from the circulation across the blood-brain barrier (BBB) into the brain. The major metabolite of 27-OHC in the brain is 7α-hydroxy-3-oxo-4-cholestenoic acid (7-HOCA). We confirm a recent report describing the presence of this metabolite in cer...

journal_title：Journal of lipid research

authors： Saeed A,Floris F,Andersson U,Pikuleva I,Lövgren-Sandblom A,Bjerke M,Paucar M,Wallin A,Svenningsson P,Björkhem I

更新日期：2014-02-01 00:00:00